Muscle Building Marvel - RAD140

 

 

Written by: Michelle G. Thibault
Edited by: Ryan McTeigue

RAD140, popularly known as Elite Sarms TIGHT®, is an investigational compound, which has become popular among bodybuilders, sports people and fitness enthusiasts. When looking to buy SARMs for fat loss and muscle gain, TIGHT® RAD 140 is an easy choice. It is reputed to have muscle-building and strength enhancing effects due to its high affinity with androgen receptors found in skeletal muscles, bones and connective tissues.

For those who are not so familiar with RAD 140, this article highlights the history and discovery of RAD140, and the mechanism behind why it is now considered to be Testosterone’s equal in terms of its anabolic properties - no jokes, this is what the new science is revealing to us.

RAD 140 is a potent, orally bioavailable Androgen Receptor Modulator (SARM) compound that was developed by Radius Health, Inc. It was originally designed as an experimental substance for androgen replacement therapy. Some of the potential benefits of RAD140 being tested within the research studies just to name a few; were for the treatment of conditions such as muscle wasting (cachexia), bone loss, and breast cancer. You can start to build a picture of how this product has come to be one of the most potent muscle building compounds while being non-steroidal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/

https://www.elitesarms.com/collections/individual-sarms/products/tight-rad-140

 

 

RAD 140’s Special Features

 

Tissue selectivity. The tissue selectivity of RAD140 is shown by potent androgen-like properties in bone and muscle, which is mainly anabolic. Studies demonstrated an increase in the weight of the pelvic muscles of castrated rats compared to control groups with RAD140‘s lowest tested dose of 0.1 mg/kg. Impressive!

The physique and sports scene caught on very rapidly to the muscle building effects of RAD 140 making it a popular choice when buying SARMs in Australia the USA, Canada and the EU.

However, it demonstrates diminished effects in other androgen-responsive tissues, such as prostate and seminal vesicles - this is a great thing and the reason why it doesn’t cause prostate hypertrophy or infertility.

Particularly, when administered along with testosterone, RAD140 was found to somewhat antagonize the growth effect of testosterone in prostate and seminal vesicles, proposing that RAD140 acts as a competitive Androgen Receptor ligand but with reduced activity. This means that RAD140 successfully competes with Testostorone on AR sites blocking the hormone from attaching to these negative receptor sites, thus inhibiting synthetic testosterones potential tumor-promoting actions on reproductive organs. Tight® therefore, may be effective in use as protection of the prostate and other sensitive reproductive organ sites that high and long doses or testosterone have the potential to negatively effect. Ie RAD140 could be used along-side testosterone to not only enhance the positive effects but to also block any potential negative effects the synthetic testosterone can cause.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083371/


Safety.
The same study also found that while taking RAD140, despite the dramatic increases in body weight over such a short time, there was no elevation of liver enzyme transaminase levels in any of the lab mice at any dose >2 fold over its baseline value. Given the established link between oral androgen use and liver stress indicators, researchers were pleasantly surprised that even at a dose 10x greater than the fully effective dose, they saw minimal liver enzyme elevations with RAD140 - this is another very positive finding.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/

https://www.elitesarms.com/collections/individual-sarms/products/tight-rad-140

 

 

It is Neuroprotective too!

 

When testosterone levels in men start to fall due to the normal aging process, the risks of dysfunction and disease in androgen-responsive tissues increases, which amazingly, also includes the brain!! After all the brain is a large organ made up of proteins such like any other organ in the body except is carries out a much grander role - allowing us to experience reality.

Since testosterone therapy can cause a potential increase in the risk of developing prostate cancer, scientists have turned to SARMs to overcome these limitations. Studies have discovered that RAD140 lacks significant androgen action in the prostate (the main hardware in the reproductive system) but exerts highly positive effects in selective androgen-responsive tissues including BRAIN NEURONS!

In a 2014 study by the Endocrine Society, RAD140’s effects were investigated in cultured rat neurons and male rat brain. RAD140 was shown to provide neuroprotection, and increased resilience from neurodegenerative diseases.

The study concluded, that by administering RAD140, it activates androgen-protective pathways that reduce cell death induced by 3 factors: Aβ peptides (coming from amyloid deposits seen in Alzheimer’s), apoptosis activator II (seen in tumor and cancer cells), and hydrogen peroxide (produced during cell injury).

Like Testosterone, RAD140 has the ability to protect the brain but also help it to function / perform better. However unlike Testosterone, RAD140 is extremely highly selective, activating androgen receptors in the muscles we use to work out and the brain tissue we use to develop business ideas, and in-general just think and continue being able to think effectively, long into our years.

We here are Elite Sarms believe we are only just looking at the tip of the ice-burg with the muscle building Marvel - RAD140 and we are exciting to continue bringing you research on what the studies continue to reveal about this amazing compound. In the meantime if you would like to conduct your own personal research and see what this amazing compound can do for your physique and for your brain performance, check out Elite Sarms Tight® (RAD140) here.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/

https://pubmed.ncbi.nlm.nih.gov/16011741/

Leave a comment

All comments are moderated before being published

Shop now

You can use this element to add a quote, content...