Circadian Rhythm and Rejuvenation. How Re-Setting The Rhythm Can Potentiate Your Entire Body

 

 

By: M.G. Thibault. Edited Ryan McTeigue


Your Circadian rhythm controls many aspects of your health from sleep to heart rate, hormone secretion, blood pressure, neurological function, and metabolic routes. As you can see many things which can either improve of decrease an athletes performance.

Today, researchers are learning that the circadian rhythm can also be a new target to help rejuvenate the whole body and extend lifespan. This area of research holds so much potential that lab studies from MIT discovered a link between a healthy circadian rhythm and the constant rejuvenation of an organism. Scientists are positive that by enhancing the body’s circadian cycle, one can prevent and treat diseases not only due to aging but disorders that arise from very active (fitness lovers) or strenuous lifestyles (most humans on earth).

You can’t really exaggerate the importance of this research since many health conditions arise from the disruption of our circadian rhythms especially in these modern times. These increasing disturbances in one’s “body clock” is strongly linked with inflammatory states including neurodegenerative diseases.

Whether disorders in the body arise from stressful daily routines, environmental toxins, excessive physical demand, or simply from aging, at the molecular level, thanks to our scientific community, a person can now restore the body’s circadian rhythm to a more youthful state and effect complete rejuvenation in the body.

https://news.mit.edu/2013/the-link-between-circadian-rhythms-and-aging-0620

https://pubmed.ncbi.nlm.nih.gov/27885006/


Based on the ongoing stream of confirmatory data, there are particular compounds that can help synchronize and restore the proper operation of the body’s circadian rhythm. This article will prove to be of great value if you feel out-of-sync with your current sleeping habits. This article is for the following person who is:

- Consistently working out

- Regularly engaging in sports or outdoor activities

- Involved in mentally demanding tasks as part of the job

- Constantly multi-tasks in a daily basis

- Looking to increase their productivity levels

- Gearing up for a more challenging workload ahead

- Experiencing problems due to inflammatory conditions

- Already feeling age-related effects in performance


If one of more factors on this list describe YOU, your priority right now is to regain control over the proper function of your circadian rhythm in order to re-claim your essential health and rejuvenate your body to its highest level. Below we outline a few hacks which can greatly help with this task::


1. Melatonin

Scientists have found that we can keep our circadian clock in sync through melatonin supplementation. This unique nutritional approach targets both central and peripheral clocks to regulate circadian rhythm. When the brain’s pineal gland secretes melatonin, this helps normalize hormone production, neurotransmitter functions and healthy sleep patterns.

A 2017 study shows that daily supplementation of 10 mg of Melatonin in subjects with obesity decreased oxidative stress and facilitated body weight reduction while improving the body’s antioxidant defence. This factor translates to healthy, normal individuals as well.

https://pubmed.ncbi.nlm.nih.gov/25287733/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632922/

2. SIRT 1 activators

Researchers have shown that SIRT1 (Sirtuin) helps regulate circadian rhythm and protect against the diseases of aging. The SIRT1 gene is also shown to protect against diseases of aging and plays a key role in controlling the body’s circadian rhythms. Conversely, loss of SIRT1 function impairs circadian control in young mice, mimicking what happens in normal aging. Activating the SIRT1 pathway to sustain adequate circadian control and thus reverse aging is a probable therapeutic target that Regenerative Medicine is currently looking into.

By activating the SIRT1 pathway, damage in our DNA created by environmental factors, stress, energy deprivation, and toxins that the body accumulates are constantly being replenished and cell division continues to ensue.

Sirtuin-activating compounds include ginseng, resveratrol, quercetin, polyphenols found in bitter vegetables, cacao, curcumin, ginger, and DHA sourced from fatty fish, eggs, and algae. So ensure you add greens to your daily meals and consider into adding the aforementioned herbal and food supplements into your weekly routine - test it out and see if you feel better after at least 14 days of consistent usage.

https://pubmed.ncbi.nlm.nih.gov/32084459/

3.Rev-erb-α Agonists

Rev-erb-α is critical for the proper timing of the core clock machinery, regulating many metabolic functions, which include lipid and bile acid metabolism, gluconeogenesis, and the body’s inflammatory response. Rev-erb-α ligands, specifically agonists or activators, modify the transcriptional activity (telling the body what to do) and suggest that Rev-erb-α may serve as a promising target for the treatment of circadian alterations of metabolic pathways.

Rev-erb-α modulation was proven to be efficient in phase-advance sleep disorders commonly seen in the aging population, while it helps correct delayed circadian rhythms, frequently seen in individuals with super-active or very stressful lifestyles. In short compounds such as SR9009 can help to balance the circadian rhythms in both sleep deprived and overly-active individuals - assisting in rejuvenation and regeneration of the entire body. Leading to more energy to train, work and do more of the things you love doing!

Rev-Erbα agonists such as Hyper Lean SR9009 has been proposed to coordinate circadian metabolic responses while maintaining the timely schedule of wakefulness, sleep, body temperature, and hormone regulation which in turn facilitates a myriad of biochemical pathways. Therefore, Rev-erb-α ligands may be useful in resetting the Circadian clock into its youthful resonance and efficiency.

You can find Elite Sarms Rev-erb-α Agonist Hyper Lean® (SR9009) here.

Sweet dreams,

-ES


https://www.elitesarms.com/collections/individual-sarms/products/hyper-lean-sr9009

https://journals.physiology.org/doi/full/10.1152/japplphysiol.00570.2009

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